Process Analytical Technology (PAT) in Pharmaceuticals
Process Analytical technology (PAT) is an important methodology in the design of pharmaceutical manufacturing process. It’s simply a method or methods that are most necessary when producing drugs, where controls and analysis are placed to ensure the quality of raw materials used and the process in manufacturing is ideal in order to produce a final product of high and best quality. This is made possible through proper measurement and calibration of critical process which are important variables or parameters that have direct impact to the pharmaceutical production process and product quality. Pharmaceutical products have great significance in health care, which may include treatment, managing diseases and other health defect regulation, the pharmaceutical manufacture needs to put into consideration regulatory process and great engineering know how, alongside quality technology, which can stand up to the challenge as we advance in technology and science in the industry. Process analytical technology (PAT) Frame work is simply quality control.
There are factors that influences PAT frame work, ad these includes;Passage of Administration; This talks about how the drugs are taken. Some are in tablets, capsules, creams and liquid (syrup). They can be ingested through the mouth, some passed via injections, ocular, nasal, rectal etc.Pharmacokinetic characteristics of the drugs:This factor, talks about how the drugs move in the body, or interact with it. It also talks about its time of absorption, how it is distributed and how it is excreted. This can help to also know how long the drug would stay in the body or how long its effect will have on the individual.
Toxicological characteristics; This is very important as it tells how harmful a drug can be or how it affects a particular individual. This also helps in determining the method of application or administration. For example a virginal cream to top an infection cannot be swallowed because it will have a bad effect to the digestive system. Also it helps to identify drugs that can be harmful if taken by some individual in delicate health position.Chemical, physical, biopharmaceutical characteristics;This how to deal with the chemical components of the drug and how it reacts to other properties or different external environment like temperature, humidity, which has to do with mostly storage.
This tells how the drug should be packaged and this is made possible by quality assurance and process analytical technology (PAT). This creates quality products that get to the consumers. Process analytical technology (PAT) analysis goes a long way to help the health regulatory system or body in creating a standard for every pharmaceutical company on how and what they should take into consideration before their drugs hit the public.There are principles or steps to be taken into consideration when one has to deal with pharmaceutical product designing and its process in manufacturing. This principles regulates various materials and process used in production. Also because of the constant rise in technological advancement in the pharmaceutical world, and the world In general today, there have been a lot of progress when it comes to chemical composition,